All posts tagged: Osteochondroprogenitor

PI3Kα Inhibition Blocks

PI3Kα Inhibition Blocks Osteochondroprogenitor Specification and the Hyper-Inflammatory Response to Prevent Heterotopic Ossification

Introduction Heterotopic ossification (HO) is a disorder characterized by ectopic bone formation at extraskeletal sites, including skeletal muscle and connective tissues. Trauma-induced HO develops as a common post-operative complication after orthopedic surgeries (e.g., hip arthroplasty), blast injuries, deep burns and nervous system injuries (Hwang et al., 2022). In addition to trauma- induced HO, fibrodysplasia ossificans […]

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