All posts tagged: BLU-782

ALK2 Inhibitor

An ALK2 Inhibitor, BLU-782, Prevents Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease driven by gain-of-function variants in activin receptor-like kinase 2 (ALK2), the most common variant being ALK2R206H . In FOP, ALK2 variants display increased and dysregulated signaling through the bone morphogenetic protein (BMP) pathway resulting in progressive and permanent replacement of skeletal muscle and connective tissues with […]

Read more