Introduction Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disease with an estimated prevalence of 1:1.2–1.5 million [1]. It is among the most catastrophic forms of heterotopic ossification (HO) [2] because of the progressive, irreversible accumulation of heterotopic bone and subsequent loss of mobility and independence. FOP is caused by activating mutations (mostly, the highly […]
